AskDefine | Define encephalitis

Dictionary Definition

encephalitis n : inflammation of the brain usually caused by a virus; symptoms include headache and neck pain and drowsiness and nausea and fever (`phrenitis' is no longer in scientific use) [syn: cephalitis, phrenitis] [also: encephalitides (pl)]

User Contributed Dictionary

English

Etymology

From ἐγκέφαλος (from ἐν + κεφαλή) + -itis

Noun

encephalitis (plural: encephalitides)

Derived terms

See also

Translations

inflammation of the brain

Extensive Definition

Encephalitis is an acute inflammation of the brain, commonly caused by a viral infection. It can be caused by a bacterial infection such as bacterial meningitis spreading directly to the brain (primary encephalitis), or may be a complication of a current infectious disease like rabies or syphilis (secondary encephalitis). Certain parasitic or protozoal infestations, such as toxoplasmosis, malaria, or primary amoebic meningoencephalitis, can also cause encephalitis in people with compromised immune systems. Lyme disease may also cause encephalitis. Bartonella henselae can also lead to this. Brain damage occurs as the inflamed brain pushes against the skull, and can lead to death.

Symptoms

Patients with encephalitis suffer from fever, headache and photophobia with weakness and seizures also common. Less commonly, stiffness of the neck can occur with rare cases of patients also suffering from stiffness of the limbs, slowness in movement and clumsiness depending on which specific part of the brain is involved. The symptoms of encephalitis are caused by the brain's defense mechanisms activating to get rid of the infection. .

Etiology

Encephalitis may be caused by a variety of afflictions. One such affliction is rabies. Encephalitis may also be caused by HIV. The major causes of encephalitis outbreaks all over the world are viruses like Japanese Encephalitis, West Nile, Chandipura virus, St. Louis Encephalitis, Equine Encephalitis, La Crosse encephalitis, Murray Valley encephalitis virus, California encephalitis virus, Tick-borne meningoencephalitis, Herpes simplex, Influenza A virus. Less common are e.g. RSSE (Russian spring-summer encephalitis) viruses.

Diagnosis

Adult patients with encephalitis present with acute onset of fever, headache, confusion, and sometimes seizures. Younger children or infants may present irritability, anorexia and fever.
Neurological examinations usually reveal a drowsy or confused patient. Stiff neck, due to the irritation of the meninges covering the brain, indicates that the patient has either meningitis or meningeoncephalitis. Examination of the cerebrospinal fluid obtained by a lumbar puncture procedure usually reveals increased amounts of protein and white blood cells with normal glucose, though in a significant percentage of patients, the cerebrospinal fluid may be normal. CT scan often is not helpful, as cerebral abscess is uncommon. Cerebral abscess is more common in patients with meningitis than encephalitis. Bleeding is also uncommon except in patients with herpes simplex type 1 encephalitis. Magnetic resonance imaging offers better resolution. In patients with herpes simplex encephalitis, electroencephalograph may show sharp waves in one or both of the temporal lobes. Lumbar puncture procedure is performed only after the possibility of prominent brain swelling is excluded by a CT scan examination. Diagnosis is often made with detection of antibodies in the cerebrospinal fluid against a specific viral agent (such as herpes simplex virus) or by polymerase chain reaction that amplifies the RNA or DNA of the virus responsible (such as varicella zoster virus).

Treatment

Treatment is usually symptomatic. Reliably tested specific antiviral agents are available only for a few viral agents (e.g. acyclovir for herpes simplex virus) and are used with limited success for most infection except herpes simplex encephalitis. In patients who are very sick, supportive treatment, such as mechanical ventilation, is equally important.

Encephalitis lethargica

Encephalitis lethargica is an atypical form of encephalitis which caused an epidemic from 1917 to 1928, resulting in millions of deaths worldwide. Those who survived sank into a semi-conscious state that lasted for decades until the Parkinsons drug L-dopa was used to revive those still alive in the late 1960s by Oliver Sacks.
There have been only a small number of isolated cases in the years since, though in recent years a few patients have shown very similar symptoms. The cause is now thought to be either a bacterial agent or an autoimmune response following infection.

Herpes simplex encephalitis

Herpes simplex encephalitis is caused by the herpes simplex virus that manifests in oral cold sores or genital sores. When this triggers brain inflammation, which occurs in 10% of cases of encephalitis (2 cases per million people), half of all untreated patients die. Brain damage, partial paralysis, seizures, hallucinations and an altered state of consciousness are all common symptoms. HSE can be passed from mother to child during birth in rare cases, where symptoms include lethargy, tremors, irritability, seizures and poor feeding in the first two weeks after birth.

Limbic system encephalitis

In a small number of cases, called limbic encephalitis, the pathogens responsible for encephalitis attack primarily the limbic system (a collection of structures at the base of the brain responsible for basic autonomic functions).

See also

References

External links

encephalitis in Bulgarian: Енцефалит
encephalitis in German: Enzephalitis
encephalitis in Spanish: Encefalitis
encephalitis in Esperanto: Encefalito
encephalitis in French: Encéphalite
encephalitis in Hindi: मस्तिष्क ज्वर
encephalitis in Korean: 뇌염
encephalitis in Croatian: Encefalitis
encephalitis in Indonesian: Ensefalitis
encephalitis in Italian: Encefalite
encephalitis in Latin: Encephalitis
encephalitis in Hungarian: Agyvelőgyulladás
encephalitis in Dutch: Hersenontsteking
encephalitis in Japanese: 脳炎
encephalitis in Polish: Zapalenie mózgu
encephalitis in Portuguese: Encefalite
encephalitis in Russian: Энцефалит
encephalitis in Simple English: Encephalitis
encephalitis in Finnish: Aivotulehdus
encephalitis in Swedish: Hjärninflammation
encephalitis in Telugu: మెదడువాపు
encephalitis in Vietnamese: Viêm não
encephalitis in Turkish: Ensefalit
encephalitis in Chinese: 脑炎

Synonyms, Antonyms and Related Words

adenoiditis, adrenitis, appendicitis, arteritis, arthritis deformans, arthritis fungosa, arthritis pauperum, atrophic arthritis, atrophic inflammation, blennorrhagic arthritis, brain fever, bronchitis, bunion, bursitis, capillaritis, carditis, catarrh, catarrhal inflammation, cerebellitis, cerebral meningitis, cerebritis, cerebrospinal meningitis, chronic infectious arthritis, chronic inflammation, cirrhotic inflammation, climactic arthritis, clitoritis, colitis, collagen disease, conjunctivitis, cystitis, degenerative arthritis, diffuse inflammation, endocarditis, enteritis, equine encephalomyelitis, exudative inflammation, fibroid inflammation, focal inflammation, gastritis, gingivitis, glossitis, gonococcal arthritis, gonorrheal arthritis, gonorrheal rheumatism, gout, gouty arthritis, hemophilic arthritis, hepatitis, hyperplastic inflammation, hypertrophic arthritis, hypertrophic inflammation, infectional arthritis, infectious hepatitis, inflammation, irritable bowel syndrome, laryngitis, lumbago, lumbar rheumatism, mastoiditis, meningitis, menopausal arthritis, metastatic inflammation, metritis, milk leg, mucous colitis, mumps meningitis, myelitis, necrotic inflammation, nephritis, neuritis, obliterative inflammation, ophthalitis, ophthalmia, orchitis, osseous rheumatism, osteitis, osteoarthritis, osteomyelitis, otitis, ovaritis, paradental pyorrhea, penitis, pericarditis, periodontitis, peritonitis, pharyngitis, phlebitis, podagra, proliferative arthritis, prostatitis, pyonephritis, pyorrhea, pyorrhea alveolaris, reactive inflammation, rheumatism, rheumatiz, rheumatoid arthritis, rhinitis, sclerosing inflammation, seroplastic inflammation, serous inflammation, serum hepatitis, simple inflammation, sinusitis, spastic colon, specific inflammation, subacute rheumatism, suppurative arthritis, suppurative inflammation, syphilitic arthritis, tennis elbow, testitis, thrombophlebitis, tonsilitis, torticollis, toxic inflammation, traumatic inflammation, tuberculous arthritis, tuberculous rheumatism, ulcerative colitis, uratic arthritis, ureteritis, urethral arthritis, urethritis, uteritis, vaginitis, vertebral arthritis, visceral rheumatism, vulvitis, wryneck
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